Washing machine

A laundry machine for viral vaccines

A purification process for vaccines produced via a measles vector platform will soon lead to a more flexible, reproductive and economic process contributing to the faster development and production of vaccines.

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Hands holding a vaccine needle

Beyond the shot: Biocatalysis unlocks sustainable pseudouridine production for mRNA vaccines

mRNA vaccines gained widespread notoriety for their revolutionary power in combating the Corona pandemic. But behind the scenes, a silent hero called pseudouridine plays a crucial role in maximising their efficacy and safety. Pseudouridine, a modified RNA building block, has the remarkable ability to increase RNA stability and fine-tune immune responses, making it a valued component in the world of mRNA therapeutics. However, with the increasing demand for these breakthrough vaccines, the question arises: how can we produce pseudouridine sustainably without compromising efficiency or environmental impact?

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Geysir, hot spring

Back to the roots – Archaea save the world

Living fossils allow us a glimpse into a time long past, for they have changed little or not at all over millions of years. The platypus or the horseshoe crabs are well-known representatives from the world of animals; among plants, horsetail, ginkgo or the box tree are considered such living fossils. But the world of microorganisms can also come up with living fossils: the so-called archaea are a special group of microorganisms, which are characterised by a special composition of the cytoplasmic membrane and sometimes also through specific cell envelope that is not found in bacteria or eukaryotic organisms…

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Repairing spinal cord injuries with nanotechnology

A Europe-wide project named “Piezo4Spine” sets the high goal of developing a novel therapy against spinal cord injuries (SCI). Based on the latest findings in materials science, regenerative medicine and nanotechnology, research is being conducted on a 3D-theramesh equipped with bioactive nanocarriers that delivers therapeutic agents to the site of the lesion through electrical stimulation. These bioactive ingredients activate the neuronal regeneration processes after an SCI has occurred. If successful, this technology could be useful in the future for pathologies such as Alzheimer’s or Parkinson’s disease, among others.

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opium poppy plant

Enabling Alkaloid production in engineered poppy cells

Opiate alkaloids such as morphine and codeine are important pharmaceutical ingredients used to treat severe pain. Morphine is even classified as an essential medicine by the World Health Organization (WHO). Opiate-based medications are crucial to provide normal life for patients who need long-term pain management due to living with terminal cancer, sickle cell disease, COPD- related dyspnea, (etc.). Unfortunately, morphine is practically unavailable in low- and middle-income countries leaving patients in suffering.

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Chemo-Enzymatic Route Scouting

You have a complex chemical process that is no longer competitive? Countries with low salary levels are beginning to gain market share for cost reasons? Let acib solve your problems by discovering new and cost-efficient routes for chemo-enzymatic synthesis of your target compound(s).

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