In view of the antibiotic resistance crisis, identifying new targets to establish robust intervention strategies is urgently needed. Targeting the shikimate pathway is a highly promising approach, as exemplified by the blockbuster herbicide glyphosate.
Background
The shikimate pathway is vital to bacteria, fungi, apicomplexa, and plants but absent in mammals. The pathway comprises seven enzymes, and its inhibition is detrimental to the organism, as exemplified by the highly efficient herbicide glyphosate, which inhibits the sixth enzyme of this pathway. Therefore, the enzymes of the shikimate pathway are highly promising targets for intervention strategies, especially considering the current antibiotic resistance crisis. Potent inhibitors of these targets, including chorismate synthase—the last enzyme of the shikimate pathway, would represent antibiotics (but also antimycotics/fungicides) insusceptible to existing resistance mechanisms.
Technology
Offer
We offer the development and optimization of potent chorismate synthase inhibitors that have the potential to become the next-generation antibiotics. The intellectual property and compounds developed in our project would fully belong to our investor/industrial partner.
