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Cultured Meds: Next-Gen Pharma

Ever wondered how to produce essential pharmaceuticals more affordably and sustainably? acib is going to revolutionize the production of plant-derived bioactive molecules by developing a plant cell-based, bioreactor-compatible technology to defeat the limitations of traditional manufacturing approaches. Check it out …

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NMR-based metabolomics

Understanding the intricacies of metabolite fingerprints, their variations and absolute concentrations is paramount for a diverse array of studies. This includes biomarker studies, mechanistic inquiries, metabolic engineering endeavors, or quality assessments of complex mixtures.

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The CHO-cell technology advantage

acib has spearheaded for over a decade an international collaborative effort to unlock the potential of CHO-cells, addressing the main challenges of cell-line optimization. Benefit from reduced time-to-market and lower production cost and let acib streamline your process!

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Enzyme discovery and development for polymer processing

The research field of polymer & environmental biotechnology focusses on the development of biotechnical and enzymatic strategies related to polymer / material processing and environmental aspects. The expertise ranges from function-based enzyme development, in silico screenings and enzyme activation to estimate the biodegradation and fermentation pilots.​

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Fruit peels waste valorization

Did you know that food waste valorisation is currently at the centre of debates on the development of various “circular bioeconomy“ models? Fruit waste, in particular, represents an incredible sustainable and renewable reserve for the extraction and/or production of various products, which include well the production of biopolymers for food packaging.

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Advanced 3D-Bioprinting

3D-bioprinting is revolutionizing research and medicine by enabling the precise creation of intricate 3D structures using both living cells and biomaterials. Let acib help you capitalize on this technology to advance novel scaffolds, tissue engineering, drug testing and personalized medicine!

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The Compostable Bioprocess

If life science would be a country, it would rank third in plastic waste production, and 5th in CO2 emission. We need to become more sustainable in terms of energy and plastic use. Sterilization before, and inactivation after use requires vast amounts of energy and water, while single use plastics are from petrochemical plastic and are incinerated after use.

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Yeast-based Ginsenoside-production

Ginseng is among the most famous health-promoting plants in the world. But did you know that ginseng has a very high cost of production? acib is going to change that by developing an industrial yeast for ginsenoside production and is looking for interested companies!​

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Natural vegan cholesterol

Did you know that cholesterol is absolutely vital for our cells and a very popular ingredient in a wide range of cosmetics? Did you also know that cholesterol is animal derived, and naturally produced vegan cholesterol is painfully missing on the market? Let’s change that with acib’s cholesterol-producing yeast!

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Lithium-Bioleaching

Europe’s Green Deal largely depends on lithium imports, but there are environmental concerns against mining in Europe. What if there would be a green, environmentally-friendly ‘bio-mining’ alternative for Europe?

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A biocatalytic route to C-nucleosides

Did you know that C-nucleosides are essential constituents of modern mRNA vaccines? Were you aware that, up until now, there have been limited options for efficient chemical syntheses? acib changed all that with its recent work (published in Nat.Commun).

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Lipidomics analysis

Lipids are essential structural components of cellular membranes. These membranes confer the ability to separate living entities from their surrounds. However, lipids have many more highly relevant functions, including energy storage, transport and signaling.

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Protein QC

Qualitative LC – MS (/MS) analysis is the method of choice for quality control of proteins. We use high resolution mass spectrometers to identify intact protein masses and peptide fragment fingerprints to determine the amino acid sequence and its modification(s).

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Glutathione redox ratio

Glutathione (γ-L-glutamyl-L-cysteinyl-glycine) is the main endogenous, cellular, thiol-based antioxidant existing in reduced (GSH) and oxidized (GSSG) forms. In healthy cells, the ratio of GSH:GSSG is actively kept higher than 100:1 but different stress-conditions can affect this balance thus it can be used as a readout of cellular redox state.

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Metabolomic analysis

Knowledge of key biosynthetic steps and bottlenecks is a prerequisite for effective metabolic engineering of production strains. Not only the immediate biosynthetic precursors but also the general energetic and oxidative state of the production host can significantly influence achievable yields and quality of bioproducts.

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Proteomics Analysis

LC – MS (/MS) analysis is the method of choice for proteomics. We use high resolution mass spectrometers to identify and relatively quantify thousands of proteins and their modification(s) and then perform statistic and bioinformatic analyses to determine differentially regulated proteins and pathways.​

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Secondary Metabolites

As secondary metabolites are produced with the purpose to confer a selective advantage of the host organism they are an excellent source of novel bioactive compounds with great therapeutic potential for e.g. anti-biotics, anti-viral drugs and biological fungicides.

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Rejuvenated yeasts for better production

You want to save money on expensive fermentation processes and speed them up? Young and viable cells provide a better fermentation performance. acib’s technology rejuvenates your yeast culture to increase process productivity withouth affecting other parameters.

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Novel treatment options for precision oncology

Immune evasion is a hallmark of cancer, contributing signifcantly to the progression of malignancies and associated mortalities. An interdisciplinary approach lead by acib can assess personalized treatment options for patients, as well as lay the foundation to designing novel treatments.

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Fructose Reduction for Healthy Drinks

You want healthy drinks with all the valuable ingredients and a good taste, but without or at least with less sugar? The good news is: You are not alone! The bad news is: It’s difficult to achieve with current technologies … Let’s develop some better ones!

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Rendering of a DNA molecule

Rapid Sepsis Diagnostics

acib has developed a new diagnostic tool for early sepsis detection through novel biomarkers based on circulating-free nucleic acids. The test allows for detection of sepsis 2-3 days before first symptoms occur and shows >80% accuracy.

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Research for a better world

acib’s vision is a world without suffering and with affordable access to food and medicine for all the people on this world. acib’s mission is to enable cost-effective and environmentally friendly new processes and products through the development of new technologies.

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Improving adhesion of preadipocytes and muscle stem cells

Coating proteins are part of the extracellular matrix (ECM) and are widely used in the pharmaceutical industry, medicine, and research to improve the adhesion of mammalian cells to surfaces/tissues in vivo and in vitro. Of the several hundred ECM proteins, only a few proteins are widely used for coating, with little research into their optimization.

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Image shows part of the molecule perfluorooctanesulfonic acid, in the background an aerial photo of a stretch of coast

Biotechnological PFAS-degradation

There are compounds so stable and inert that their potential for innovation and industrial applications seemed endless … and they have been produced in huge amounts. Their global accumulation in both environments, wildlife and humans, however, have lots of detrimental effects, but since they are so stable, there is nothing that we can do – or is there?

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