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Prebiotics

Did you know that the market for prebiotics is expected to increase by 11.3% per year until 2030? Health-conscious customers, as well as new applications in the feed industry are driving demand. With acib’s expertise on prebiotic bioproduction, companies can confidently venture into this lucrative market. Seize this opportunity!

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mcl-PHAs: Eco-Friendly Elastic Polymers

Did you know that tire abrasion and washing of synthetic textiles are main contributors to microplastic pollution in the environment? There is an urgent need for bio-based and fully biodegradable alternatives. However, some features have been challenging to replace, such as the elasticity of some plastics. Discover how acib has found a solution that can also help combat climate change …

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Chemo-enzymatic route to alkaloids

The reliable production of alkaloids, including the pain medication precursors (R)-reticuline and salutaridine promorphian, is absolutely critical for the pharmaceutical industry. However, traditional methods rely on plant extraction, leading to supply chain vulnerabilities.

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Bio-based alkanes/alkenes production

Flavors and fragrances, cosmetics, lubricants, surfactants, pesticides, fine chemicals, bioplastics, biofuels, detergents, adhesives, solvents, dispersants for dyes, textile finishing – the potential applications of bio-based alkanes and alkenes seem almost endless. At acib, we provide the tools to make this vision a reality.

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Yeast surface display: High-end protein engineering

Yeast surface display represents a powerful protein lab)
engineering technology, enabling a wide range of applications including the generation of novel antigen binding sites (also in non-antibody proteins), affinity maturation, construction of pH-dependent binding sites and protein stabilization, among many others.

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Cultured Meds: Next-Gen Pharma

Ever wondered how to produce essential pharmaceuticals more affordably and sustainably? acib is going to revolutionize the production of plant-derived bioactive molecules by developing a plant cell-based, bioreactor-compatible technology to defeat the limitations of traditional manufacturing approaches. Check it out …

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NMR-based metabolomics

Understanding the intricacies of metabolite fingerprints, their variations and absolute concentrations is paramount for a diverse array of studies. This includes biomarker studies, mechanistic inquiries, metabolic engineering endeavors, or quality assessments of complex mixtures.

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The CHO-cell technology advantage

acib has spearheaded for over a decade an international collaborative effort to unlock the potential of CHO-cells, addressing the main challenges of cell-line optimization. Benefit from reduced time-to-market and lower production cost and let acib streamline your process!

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Enzyme discovery and development for polymer processing

The research field of polymer & environmental biotechnology focusses on the development of biotechnical and enzymatic strategies related to polymer / material processing and environmental aspects. The expertise ranges from function-based enzyme development, in silico screenings and enzyme activation to estimate the biodegradation and fermentation pilots.​

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Fruit peels waste valorization

Did you know that food waste valorisation is currently at the centre of debates on the development of various “circular bioeconomy“ models? Fruit waste, in particular, represents an incredible sustainable and renewable reserve for the extraction and/or production of various products, which include well the production of biopolymers for food packaging.

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Advanced 3D-Bioprinting

3D-bioprinting is revolutionizing research and medicine by enabling the precise creation of intricate 3D structures using both living cells and biomaterials. Let acib help you capitalize on this technology to advance novel scaffolds, tissue engineering, drug testing and personalized medicine!

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The Compostable Bioprocess

If life science would be a country, it would rank third in plastic waste production, and 5th in CO2 emission. We need to become more sustainable in terms of energy and plastic use. Sterilization before, and inactivation after use requires vast amounts of energy and water, while single use plastics are from petrochemical plastic and are incinerated after use.

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Yeast-based Ginsenoside-production

Ginseng is among the most famous health-promoting plants in the world. But did you know that ginseng has a very high cost of production? acib is going to change that by developing an industrial yeast for ginsenoside production and is looking for interested companies!​

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Natural vegan cholesterol

Did you know that cholesterol is absolutely vital for our cells and a very popular ingredient in a wide range of cosmetics? Did you also know that cholesterol is animal derived, and naturally produced vegan cholesterol is painfully missing on the market? Let’s change that with acib’s cholesterol-producing yeast!

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Lithium-Bioleaching

Europe’s Green Deal largely depends on lithium imports, but there are environmental concerns against mining in Europe. What if there would be a green, environmentally-friendly ‘bio-mining’ alternative for Europe?

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A biocatalytic route to C-nucleosides

Did you know that C-nucleosides are essential constituents of modern mRNA vaccines? Were you aware that, up until now, there have been limited options for efficient chemical syntheses? acib changed all that with its recent work (published in Nat.Commun).

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Lipidomics analysis

Lipids are essential structural components of cellular membranes. These membranes confer the ability to separate living entities from their surrounds. However, lipids have many more highly relevant functions, including energy storage, transport and signaling.

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Protein QC

Qualitative LC – MS (/MS) analysis is the method of choice for quality control of proteins. We use high resolution mass spectrometers to identify intact protein masses and peptide fragment fingerprints to determine the amino acid sequence and its modification(s).

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Glutathione redox ratio

Glutathione (γ-L-glutamyl-L-cysteinyl-glycine) is the main endogenous, cellular, thiol-based antioxidant existing in reduced (GSH) and oxidized (GSSG) forms. In healthy cells, the ratio of GSH:GSSG is actively kept higher than 100:1 but different stress-conditions can affect this balance thus it can be used as a readout of cellular redox state.

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Metabolomic analysis

Knowledge of key biosynthetic steps and bottlenecks is a prerequisite for effective metabolic engineering of production strains. Not only the immediate biosynthetic precursors but also the general energetic and oxidative state of the production host can significantly influence achievable yields and quality of bioproducts.

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Proteomics Analysis

LC – MS (/MS) analysis is the method of choice for proteomics. We use high resolution mass spectrometers to identify and relatively quantify thousands of proteins and their modification(s) and then perform statistic and bioinformatic analyses to determine differentially regulated proteins and pathways.​

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Secondary Metabolites

As secondary metabolites are produced with the purpose to confer a selective advantage of the host organism they are an excellent source of novel bioactive compounds with great therapeutic potential for e.g. anti-biotics, anti-viral drugs and biological fungicides.

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