Publications

Our scientific papers are mainly (90%) published as open access publications

I. Montes Serrano, D. Komuczki, A. Dürauer: A modelling approach for volumetric power input in the microscale and its utilization for the scale-up of solid-liquid mixing systems , Chemical Engineering And Processing-Process Intensification, 2023, https://doi.org/10.1016/j.cep.2023.109303

B. Kogelmann, R. Palt, D. Maresch, R. Strasser, F. Altmann, S. Kallolimath, M. D’Aoust, P. Lavoie, P. Saxena, J. Gach, H. Steinkellner: In planta expression of active bacterial GDP-6-deoxy-D-lyxo-4-hexulose reductase for glycan modulation, Plant Biotechnology Journal, 2023, https://doi.org/10.1111/pbi.14131

M. Pons Royo, T. De Santis, D. Komuczki, P. Satzer: Continuous precipitation of antibodies by feeding of solid polyethylene glycol , Separation And Purification Technology, 2023, https://doi.org/10.1016/j.seppur.2022.122373

A. Pellis, G. Gübitz, D. Ribitsch: Bio-upcycling of multi-layer materials and blends: closing the plastics loop, Current Opinion In Biotechnology, 2023, https://doi.org/10.1016/j.copbio.2023.102938

A. Frank, A. Emmerstorfer-Augustin, T. Rath, G. Trimmel, M. Nachtnebel, F. Stelzer: Bio-Polyester/Rubber Compounds: Fabrication,Characterization, and Biodegradation, Polymers, 2023, https://doi.org/10.3390/polym15122593

K. Ebner, L. Pfeifenberger, C. Rinnofner, V. Schusterbauer, A. Glieder, M. Winkler: Discovery and heterologous expression of unspecific Peroxy-genases, Catalysts, 2023, https://doi.org/10.3390/catal13010206

L. Schober, H. Dobiašová, V. Jurkaš, F. Parmeggiani, F. Rudroff, M. Winkler: Enzymatic reactions towards aldehydes: An overview, Flavour And Fragrance Journal, 2023, https://doi.org/10.1002/ffj.3739

V. Mayer, A. Frank, S. Preinsperger, P. Csar, P. Steppert, A. Jungbauer, P. Pereira Müller Aguilar: Removal of chromatin by salt-tolerant endonucleases for production of recombinant measles virus , Biotechnology Progress, 2023, https://doi.org/10.1002/btpr.3342

T. Li, A. Borg, L. Krammer, R. Breinbauer, B. Nidetzky: Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides , Biotechnology And Bioengineering, 2023, http://dx.doi.org/10.1002/bit.28354

B. Křístková, R. Rädisch, N. Kulik, M. Horvat, A. Vesel, L. Rucká, M. Grulich, F. Rudroff, A. Kádek, M. Pátek, M. Winkler, L. Martinkova: Scanning aldoxime dehydratase sequence space and characterization of a new aldoxime dehydratase from Fusarium vanettenii, Enzyme And Microbial Technology, 2023, https://doi.org/10.1016/j.enzmictec.2022.110187

N. Bernat-Camps, K. Ebner, V. Schusterbauer, J. Fischer, M. Nieto-Taype, F. Valero Barranco, A. Glieder, X. Garcia-Ortega: Enabling Growth-Decoupled Pichiapastoris Recombinant ProteinProduction based on the Methanol-FreePDH Promoter, Frontiers In Bioengineering And Biotechnology, 2023, https://doi.org/10.3389/fbioe.2023.1130583

H. Rußmayer, M. Buchetics, M. Mattanovich, S. Neubauer, M. Steiger, A. Graf, G. Koellensperger, S. Hann, M. Sauer, B. Gasser, D. Mattanovich: Customizing amino acid metabolism of Pichia pastoris for recombinant protein production, Biotechnology Journal, 2023, https://doi.org/10.1002/biot.202300033

M. Pfeiffer, B. Nidetzky: Biocatalytic cascade transformations for the synthesis of C-nucleosides and N-nucleoside analogs, Current Opinion In Biotechnology, 2023, https://doi.org/10.1016/j.copbio.2022.102873

G. Borsi, K. Motheramgari, H. Dhiman, M. Baumann, E. Sinkala, M. Ballhausen, J. Riba, N. Borth: Single-cell RNA sequencing reveals homogeneous transcriptome patterns and low variance in a suspension CHO-K1 and an adherent HEK293FT cell line in culture conditions, Journal Of Biotechnology, 2023, https://doi.org/10.1016/j.jbiotec.2023.01.006

C. Hausjell, W. Ernst, C. Grünwald-Gruber, E. Arcalis, R. Grabherr: Quantitative proteomic analysis of extracellular vesicles in response to baculovirus infection of a Trichoplusia ni cell line, Plos One, 2023, https://doi.org/10.1371/journal.pone.0281060

H. Schenk, P. Heidinger, H. Insam, N. Kreuzinger, R. Markt, F. Nägele, H. Oberacher, C. Scheffknecht, M. Steinlechner, G. Vogl, A. Wagner, W. Rauch: Prediction of hospitalisations based on wastewater-based SARS-CoV-2 epidemiology, Science Of The Total Environment, 2023, https://doi.org/10.1016/j.scitotenv.2023.162149

B. Grill, T. Pavkov-Keller, C. Grininger, B. Darnhofer, K. Gruber, M. Hall, H. Schwab, K. Steiner: Engineering TM1459 for Stabilisation against Inactivation by Amino Acid Oxidation , Chemie Ingenieur Technik, 2023, https://doi.org/10.1002/cite.202200176

V. Lambauer, A. Permann, Z. Petrasek, V. Subotic, C. Hochenauer, R. Kratzer, M. Reichhartinger: Automatic control of chemolithotrophic cultivation of Cupriavidus necator: optimization of oxygen supply for enhanced bioplasticproduction, Fermentation-Basel, 2023, https://doi.org/10.3390/fermentation9070619

R. Zahrl, R. Prielhofer, J. Burgard, D. Mattanovich, B. Gasser: Synthetic activation of yeast stress response improves secretion of recombinant proteins , New Biotechnology, 2023, https://doi.org/10.1016/j.nbt.2023.01.001

S. Schelch, M. Eibinger, J. Zuson, J. Kuballa, B. Nidetzky: Modular bioengineering of whole-cell catalysis for sialo-oligosaccharide production: coordinated co-expression of CMP-sialic acid synthase and sialyltransferase, Metabolic Engineering, 2023, https://doi.org/10.1186/s12934-023-02249-1

B. Wassermann, T. Cernava, I. Kögl, S. Goertz, S. Rietz, A. Abadi, G. Berg: Low nitrogen fertilization enriches nitrogen-fixing bacteria in the Brassica seed microbiome of subsequent generations, Journal Of Sustainable Agriculture And Environment, 2023, https://dx.doi.org/10.1002/sae2.12046

C. Siracusa, F. Quartinello, M. Soccio, M. Manfroni, N. Lotti, A. Dorigato, G. Gübitz, A. Pellis: On the selective enzymatic recycling of poly(pentamethylene 2,5-furanoate)/poly(lactic acid) blends and multiblock copolymers, Green Chemistry, 2023, http://dx.doi.org/10.1021/acssuschemeng.3c01796

M. Silva dos Santos, C. Schuster, H. Rennhofer, H. Lichtenegger, H. Peterlik, T. Causon, A. Jungbauer: Ultrathin membranes composed of branched polyethylenimine and poly[(o-cresyl glycidyl ether)-co-formaldehyde] for primary recovery of itaconic acid, Separation And Purification Technology, 2023, https://doi.org/10.1016/j.seppur.2023.123738

D. Weber, L. de Souza Bastos, M. Winkler, Y. Ni, A. Aliev, H. Hailes, D. Rother: Multi-enzyme catalysed processes using purified and whole-cell biocatalysts towards a 1,3,4-substituted tetrahydroisoquinoline, Rsc Advances, 2023, http://dx.doi.org/10.1039/d3ra01210g

L. Eidenberger, B. Kogelmann, H. Steinkellner: Plant-based biopharmaceutical engineering, Nature Reviews Bioengineering, 2023, https://doi.org/10.1038/s44222-023-00044-6

L. Martinkova, M. Grulich, M. Pátek, B. Křístková, M. Winkler: Bio-based valorization of lignin-derived phenolic compounds: a review, Biomolecules, 2023, http://dx.doi.org/10.3390/biom13050717

M. Pfeiffer, A. Ribar, B. Nidetzky: A selective and atom-economic rearrangement of uridine by cascade biocatalysis for production of pseudouridine., Nature Communications, 2023, https://doi.org/10.1038/s41467-023-37942-7

K. Leitner, K. Motheramgari, N. Borth, N. Marx: Nanopore Cas9-targeted sequencing enables accurate and simultaneous identification of transgene integration sites, their structure and epigenetic status in recombinant Chinese hamster ovary cells, Biotechnology And Bioengineering, 2023, https://doi.org/10.1002/bit.28382

M. Mozgovicz, A. Fischer, C. Brocard, A. Jungbauer, N. Lingg: L-Arginine sulfate reduces irreversible protein binding in immobilized metal affinity chromatography, Journal Of Chromatography A, 2023, https://doi.org/10.1016/j.chroma.2023.464246

A. Vyas, B. Nidetzky: Energetics of the Glycosyl Transfer Reactions of Sucrose Phosphorylase, Biochemistry, 2023, https://doi.org/10.1021/acs.biochem.3c00080

R. Pasupuleti, F. Rosato, D. Kolanovic, O. Makshakova, W. Römer, B. Wiltschi: Genetic code expansion in E. coli enables production of a functional ‘ready-to-click’ T cell receptor-specific scFv, New Biotechnology, 2023, https://doi.org/10.1016/j.nbt.2023.05.007

W. Srila, M. Baumann, M. Riedl, K. Rangnoi, N. Borth, M. Yamabhai: Glutamine synthetase knockout using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodie, Scientific Reports, 2023,

B. Kogelmann, S. Melnik, M. Bogner, S. Kallolimath, E. Stöger, L. Sun, R. Strasser, M. D’Aoust, P. Lavoie, P. Saxena, J. Gach, H. Steinkellner: A genome-edited N. benthamiana line for industrial-scale production of recombinant glycoproteins with targeted N-glycosylation , Biotechnology Journal, 2023, https://doi.org/10.1002/biot.202300323

E. Vásquez Castro, G. Memari, Ö. Ata Akyol, D. Mattanovich: Carbon efficient production of chemicals with yeasts, Yeast, 2023, https://doi.org/10.1002/yea.3909

S. Bachleitner, Ö. Ata Akyol, D. Mattanovich: The potential of CO2-based production cycles in biotechnology to fight the climate crisis, Nature Communications, 2023, http://dx.doi.org/10.1038/s41467-023-42790-6

M. Hetmann, C. Langner, V. Durmaz, M. Cespugli, K. Köchl, A. Krassnigg, C. Blaschitz, S. Groiss, M. Loibner, D. Ruau, K. Zatloukal, K. Gruber, G. Steinkellner, C. Gruber: Identification and validation of fusidic acid and flufenamic acid as inhibitors of SARS-CoV-2 replication using DrugSolver CavitomiX, Scientific Reports, 2023, https://doi.org/10.1038/s41598-023-39071-z

A. Dürauer, A. Jungbauer, T. Scharl-Hirsch: Sensors and chemometrics in downstream processing, Biotechnology And Bioengineering, 2023, https://doi.org/10.1002/bit.28499

G. Beihammer, J. König-Beihammer, B. Kogelmann, V. Ruocco, C. Grünwald-Gruber, M. D’Aoust, P. Lavoie, P. Saxena, J. Gach, H. Steinkellner, R. Strasser: An oligosaccharyltransferase from Leishmania donovani increases the N-glycan occupancy on plant-produced IgG1, Frontiers In Plant Science, 2023, https://doi.org/10.3389/fpls.2023.1233666

M. Citlali Flores Villegas, C. Rebnegger, V. Kowarz, R. Prielhofer, D. Mattanovich, B. Gasser: Systematic sequence engineering enhances the induction strength of the glucose-regulated GTH1 promoter of Komagataella phaffii, Nucleic Acids Research, 2023, https://doi.org/10.1093/nar/gkad752

A. Reinfurt, S. Fritsche, V. Biró, A. Marton, V. Ellena, E. Fekete, E. Sandor, L. Karaffa, M. Steiger: Manganese(II) ions suppress the transcription of the citrate exporter encoding gene cexA in Aspergillus nige, Frontiers In Bioengineering And Biotechnology, 2023, https://doi.org/10.3389/fbioe.2023.1292337

N. Danielewicz, F. Rosato, J. Tomisch, J. Gräber, B. Wiltschi, G. Striedner, W. Römer, J. Mairhofer: Clickable Shiga toxin B subunit for drug delivery in cancer therapy, Acs Omega, 2023, https://doi.org/10.1021/acsomega.3c00667

J. Jung, A. Borg, B. Nidetzky: Solvent Engineering for Nonpolar Substrate Glycosylation Catalyzed by the UDP-Glucose-Dependent Glycosyltransferase UGT71E5: Intensification of the Synthesis of 15-Hydroxy Cinmethylin β-d-Glucoside, Journal Of Agricultural And Food Chemistry, 2023, https://doi.org/10.1021/acs.jafc.3c04027

K. Mildau, H. Ehlers, I. Oesterle, M. Pristner, B. Warth, M. Doppler, R. Schumacher, J. Zanghellini, J. van der Hooft: specXplore: An interactive dashboard for tailored mass spectral dataexploratio, Biorxiv, 2023, https://doi.org/10.1101/2023.10.03.560677

A. Swoboda, L. Pfeifenberger, Z. Duhovic, M. Bürgler, I. Oroz-Guinea, K. Bangert, F. Weißensteiner, L. Parigger, K. Ebner, A. Glieder, W. Kroutil: Enantioselective High-Throughput Assay Showcased for the Identification of (R)- as well as (S)-Selective Unspecific Peroxygenases for C-H Oxidation, Angewandte Chemie-International Edition, 2023, https://doi.org/10.1002/anie.202312721

B. Mitic, C. Troyer, L. Lutz, M. Baumschabl, S. Hann, D. Mattanovich: The oxygen-tolerant reductive glycine pathway assimilates methanol, formate and CO2 in the yeast Komagataella phaffii, Nature Communications, 2023, https://doi.org/10.1038/s41467-023-43610-7

S. Kobalter, A. Voit, M. Bekerle-Bogner, H. Rudalija, A. Haas, T. Wrießnegger: Tuning fatty acid profile and yield in Pichia pastoris, Bioengineering, 2023, https://doi.org/10.3390/bioengineering10121412

L. Parigger, S. Grabuschnig, K. Gruber, G. Steinkellner, C. Gruber: AI-assisted structural consensus-proteome prediction of human monkeypox viruses isolated within a year after the 2022 multi- country outbreak, Microbiology Spectrum, 2023, https://doi.org/10.1128/spectrum.02315-23

R. Pasupuleti, S. Riedl, L. Saltor Núñez, M. Karava, V. Kumar, R. Kourist, B. Turnbull, D. Zweytick, B. Wiltschi: Lectin-anticancer peptide fusion demonstrates significant cancer-cell-selective cytotoxic effect and inspires the production of ‘clickable’ anticancer peptide in E. coli, Protein Science, 2023, https://doi.org/10.1002/pro.4830

L. Bernauer, P. Berzak, L. Lehmayer, J. Messenlehner, G. Oberdorfer, G. Zellnig, H. Wolinski, C. Augustin, M. Baeck, A. Emmerstorfer-Augustin: Sterol interactions influence the function of Wsc sensors, Journal Of Lipid Research, 2023, https://doi.org/10.1016/j.jlr.2023.100466

T. Rodrigues, R. Mota, L. Gales, P. Tamagnini, L. Campo-Deaño: Microrheological characterisation of Cyanoflan in human blood plasma, Carbohydrate Polymers, 2023, https://doi.org/10.1016/j.carbpol.2023.121575

J. Bitter, M. Pfeiffer, A. Borg, K. Kuhlmann, T. Pavkov-Keller, P. Sanchez-Murcia, B. Nidetzky: Enzymatic β-elimination in natural product O- and C-glycoside deglycosylation, Nature Communications, 2023, https://doi.org/10.1038/s41467-023-42750-0

A. Sigg, M. Klimacek, B. Nidetzky: Pushing the boundaries of phosphorylase cascade reaction for cellobiose production I: Kinetic model development, Biotechnology And Bioengineering, 2023, htps://dx.doi.org/10.1002/bit.28602

H. Engelmaier , C. Dattenböck, K. Petrushevska-Seebach, A. Jungbauer, N. Hammerschmidt: Intensified capture of recombinant blood coagulation factors by continuous, integrated downstream processing, Journal Of Chemical Technology And Biotechnology, 2023, https://dx.doi.org/10.1002/jctb.7546

S. Mayr, S. Wagner, R. Nagl, A. Pellis, M. Gigli, C. Crestini, M. Horvat, T. Zeiner, G. Gübitz, R. Weiss, N. Schwaiger: Physicochemical Insights into Enzymatic Polymerization of Lignosulfonates, Acs Sustainable Chemistry & Engineering, 2023, https://doi.org/10.1021/acssuschemeng.3c05521

M. Pfeiffer, B. Nidetzky: C-Ribosylating Enzymes in the (Bio)Synthesis of C-Nucleosides and C-Glycosylated Natural Products, Acs Catalysis, 2023, https://doi.org/10.1021/acscatal.3c04436

P. Kusstatscher, T. Cernava, K. Harms, J. Maier, G. Berg, C. Zachow: On-field microbial community influences postharvest root rot in sugar beet, Acta Horticulturae, 2021, https://doi.org/10.17660/ActaHortic.2021.1325.43

V. Ellena, D. Bucchieri, E. Arcalis, M. Sauer, M. Steiger: Sclerotia formed by citric acid producing strains of Aspergillus niger: Induction and morphological analysis, Fungal Biology, 2021, https://doi.org/10.1016/j.funbio.2021.01.008

C. Schuster, H. Rennhofer, H. Amenitsch, H. Lichtenegger, A. Jungbauer, R. Tscheliessnig: Metal–Insulator Transition of Ultrathin Sputtered Metals on Phenolic Resin Thin Films: Growth Morphology and Relations to Surface Free Energy and Reactivity, Nanomaterials, 2021, https://doi.org/10.3390/nano11030589

N. Hammerschmidt, H. Engelmaier , C. Dattenböck, J. Senčar, A. Jungbauer: Structured bottom section in inclined settlers for efficient continuous solid-liquid separation and washing of the solid fraction , Separation And Purification Technology, 2021, https://doi.org/10.1016/j.seppur.2020.118142

N. Lingg, M. Cserjan-Puschmann, A. Fischer, C. Brocard, M. Berkemeyer, G. Striedner, A. Jungbauer: Advanced purification platform using circularly permuted caspase-2 for affinity fusion-tag removal to produce native fibroblast growth factor 2, Journal Of Chemical Technology And Biotechnology, 2021, https://doi.org/10.1002/jctb.6666

V. Schmieder, N. Novak, H. Dhiman, L. Nguyen Ngoc, E. Serafimova, M. Baumann, H. Kildegaard, N. Borth: A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells, Biotechnology Reports, 2021, https://doi.org/10.1016/j.btre.2021.e00649

S. Schelch, M. Eibinger, S. Gross-Belduma, B. Petschacher, J. Kuballa, B. Nidetzky: Engineering analysis of multienzyme cascade reactions for 3′-sialyllactose synthesis , Biotechnology And Bioengineering, 2021, https://doi.org/10.1002/bit.27898

F. Strobl, M. Dürkop, D. Palmberger, G. Striedner: Reconsider the shear paradigm – stirring and aeration strategies in cell culture processes, Scientific Reports, 2021, https://doi.org/10.1038/s41598-021-88813-4

M. Weinguny, G. Klanert, P. Eisenhut, I. Lee, W. Timp, N. Borth: Subcloning induces changes in the DNA-methylation pattern of outgrowing colonies, Biotechnology Journal, 2021, https://doi.org/10.1002/biot.202000350

J. Messenlehner, M. Hetmann, A. Tripp, S. Wallner, P. Macheroux, K. Gruber, B. DANIEL: The catalytic machinery of the FAD-dependent AtBBE-like protein 15 for alcohol oxidation: Y193 and Y479 form a catalytic base, Q438 and R292 an alkoxide binding sit, Archives Of Biochemistry And Biophysics, 2021, https://doi.org/10.1016/j.abb.2021.108766

V. Ellena, S. Seekles, A. Ram, M. Steiger: Genome sequencing of the neotype strain CBS 554.65 reveals the MAT1-2 locus of Aspergillus niger, Bmc Genomics, 2021, https://doi.org/10.1186/s12864-021-07990-8

C. Zhong, K. Zajki-Zechmeister, B. Nidetzky: Reducing end thiol-modified nanocellulose: bottom-up enzymatic synthesis and use for templated assembly of silver nanoparticles into biocidal composite material , Carbohydrate Polymers, 2021, https://doi.org/10.1016/j.carbpol.2021.117772

K. Schwaiger, M. Cserjan-Puschmann, G. Striedner, B. Nidetzky: Whole cell-based catalyst for enzymatic production of the osmolyte 2-O-alpha-glucosylglycerol , Microbial Cell Factories, 2021, https://doi.org/10.1186/s12934-021-01569-4

A. Singh, G. Steinkellner, K. Köchl, K. Gruber, C. Gruber: Serine 477 plays a crucial role in the interaction of the SARS‑CoV‑2 spike protein with the human receptor ACE2 , Scientific Reports, 2021, https://doi.org/10.1038/s41598-021-83761-5

H. Liu, G. Tegl, B. Nidetzky: Glycosyltransferase Co‐immobilization for Natural Product Glycosylation: Cascade Biosynthesis of the C‐Glucoside Nothofagin with Efficient Reuse of Enzymes, Advanced Synthesis & Catalysis, 2021, https://doi.org/10.1002/adsc.202001549

C. Öhlknecht, S. Katz, C. Kröß, B. Sprenger, P. Engele, R. Schneider, C. Oostenbrink: Efficient In Silico Saturation Mutagenesis of a Member of the Caspase Protease Family, Journal Of Chemical Information And Modeling, 2021, https://doi.org/10.1021/acs.jcim.0c01216

J. De Vos, P. Pereira Müller Aguilar, C. Köppl, A. Fischer, C. Grünwald-Gruber, M. Dürkop, M. Klausberger, J. Mairhofer, G. Striedner, M. Cserjan-Puschmann, N. Lingg: Native hydrophobic interaction chromatography hyphenated to multi-angle light scattering detection for downstream processing in-process control of SARS-CoV-2 nucleocapsid protein produced in Escherichia coli, Analytical Chemistry (Washington), 2021, https://doi.org/10.26434/chemrxiv.14195318.v1

D. Komuczki, G. Dutra , C. Gstöttner, E. Dominguez‐Vega , A. Jungbauer, P. Satzer: Media On‐demand: Continuous reconstitution of a chemically defined media directly from solids, Biotechnology And Bioengineering, 2021, https://dx.doi.org/10.1002/bit.27738

D. Barbay, M. Mačáková, L. Sützl, S. De, D. Mattanovich, B. Gasser: Two homologs of the Cat8 transcription factor are involved in the regulation of ethanol utilization in Komagataella phaffii, Current Genetics, 2021, https://doi.org/10.1007/s00294-021-01165-4

L. Jakob, B. Beyer, C. Ferreira, N. Lingg, A. Jungbauer, R. Tscheliessnig: Protein-protein interactions and reduced excluded volume increase dynamic binding capacity of dual salt systems in hydrophobic interaction chromatograph, Journal Of Chromatography A, 2021, https://doi.org/10.1016/j.chroma.2021.462231

A. Kruschitz, L. Peinsipp, M. Pfeiffer, B. Nidetzky: Continuous process technology for glucoside production from sucrose using a whole cell-derived solid catalyst of sucrose phosphorylase, Applied Microbiology And Biotechnology, 2021, https://doi.org/10.1007/s00253-021-11411-x

M. Klimacek, C. Zhong, B. Nidetzky: Kinetics of phosphorylase-catalyzed iterative beta-1,4-glycosylation of cellobiose for biocatalytic synthesis of soluble cello-oligosaccharides, Biotechnology For Biofuels, 2021, https://doi.org/10.1186/s13068-021-01982-2

M. Klausberger, M. Dürkop, H. Haslacher, G. Wozniak-Knopp, M. Cserjan-Puschmann, T. Perkmann, N. Lingg, P. Pereira Müller Aguilar, E. Laurent, J. De Vos, M. Hofner, B. Holzer, M. Stadler, G. Manhart, K. Vierlinger, M. Egger, L. Milchram, E. Gludovacz, N. Marx, C. Köppl, C. Tauer, J. Beck, D. Maresch, C. Grünwald-Gruber, F. Strobl, P. Satzer, G. Stadlmayr, U. Vavra, J. Huber, M. Wahrmann, F. Eskandary, M. Breyer, D. Sieghart, P. Quehenberger, G. Leitner, R. Strassl, A. Egger, C. Irsara, A. Griesmacher, G. Hoermann, G. Weiss, R. Bellmann-Weiler, J. Loeffler-Ragg, N. Borth, R. Strasser, A. Jungbauer, R. Hahn, J. Mairhofer, B. Hartmann, N. Binder, G. Striedner, L. Mach, A. Weinhäusel, B. Dieplinger, F. Grebien, W. Gerner, C. Binder, R. Grabherr: A comprehensive antigen production and characterisation study for easy-to-implement, specific and quantitative SARS-CoV-2 serotests, Ebiomedicine, 2021, https://doi.org/10.1016/j.ebiom.2021.103348

C. Kröß, P. Engele, B. Sprenger, A. Fischer, N. Lingg, M. Baier, C. Öhlknecht, B. Lier, C. Oostenbrink, M. Cserjan-Puschmann, G. Striedner, A. Jungbauer, R. Schneider: PROFICS: A bacterial selection system for directed evolution of proteases, Journal Of Biological Chemistry, 2021, https://doi.org/10.1016/j.jbc.2021.101095

J. Garrigós-Martínez, A. Weninger, J. Montesinos-Seguí, C. Schmid, F. Valero Barranco, C. Rinnofner, A. Glieder, J. Garcia-Ortega: Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9, Microbial Cell Factories, 2021, https://doi.org/10.1186/s12934-021-01577-4

J. Štor, D. Ruckerbauer, D. Széliová, J. Zanghellini, N. Borth: Towards rational glyco-engineering in CHO: from data to predictive models, Current Opinion In Biotechnology, 2021, https://doi.org/10.1016/j.copbio.2021.05.003

F. Bertolini, M. Soccio, S. Weinberger, G. Guidotti, M. Gazzano, G. Guebitz, N. Lotti, A. Pellis: Unveiling the enzymatic degradation process of bio-based thiophene polyesters, Frontiers In Chemistry, 2021, https://doi.org/10.3389/fchem.2021.771612

J. Bååth, V. Novy, L. Carneiro, G. Guebitz, L. Olsson, P. Westh, D. Ribitsch: Structure-function analysis of two closely related cutinases from Thermobifida cellulosilytic, Journal Of Biological Chemistry, 2021, https://doi.org/10.1002/bit.27984

F. Quartinello, K. Kremser, H. Schoen, D. Tesei, L. Ploszczanski, M. Nagler, S. Podmirseg, H. Insam, G. Piñar, K. Sterflinger, D. Ribitsch, G. Gübitz: Together is better: the rumen microbial community as biological toolbox for degradation of synthetic polyesters, Frontiers In Bioengineering And Biotechnology, 2021, https://doi.org/10.3389/fbioe.2021.684459

J. Bååth, V. Novy, L. Carneiro, G. Gübitz, L. Olsson, P. Westh, D. Ribitsch: Comparison of a fungal and a bacterial laccase for lignosulfonate polymerization , Process Biochemistry, 2021, https://doi.org/10.1016/j.procbio.2021.07.001

A. Sigg, M. Klimacek, B. Nidetzky: Three-level hybrid modeling for systematic optimization of biocatalytic synthesis: α-glucosyl glycerol production by enzymatic trans-glycosylation from sucrose, Biotechnology And Bioengineering, 2021, https://doi.org/10.1002/bit.27878

S. Spiess, J. Kucera, H. Seelajaroen , A. Sasiain, S. Thallner, K. Kremser, D. Novak, G. Gübitz, M. Haberbauer: Impact of Carbon Felt Electrode Pretreatment on Anodic Biofilm Composition in Microbial Electrolysis Cells, Biosensors-Basel, 2021, https://doi.org/10.3390/bios11060170

A. Dumitriu, A. May, Ö. Ata-Akyol, D. Mattanovich: Fermenting Futures: an artistic view on yeast biotechnolog, Fems Yeast Research, 2021, https://doi.org/10.1093/femsyr/foab042

G. Gübitz: Delivery of Biomolecules Using Chitosan Wound Dressings, In: Advances In Polymer Science. Springer, Berlin, Heidelberg, 2021, https://link.springer.com/chapter/10.1007/12_2021_95

F. Fabbri, F. Bertolini, G. Gübitz, A. Pellis: Biocatalyzed synthesis of flavor esters and polyesters: a design of experiments (DoE) approach, International Journal Of Molecular Sciences, 2021, https://doi.org/10.3390/ijms22168493

D. Schwendenwein, A. Ressmann, M. Entner, V. Savic, M. Winkler, F. Rudroff: Chemo-enzymatic cascade for the generation of fragrance aldehyde, Catalysts, 2021, https://doi.org/10.3390/catal11080932

I. Montes Serrano, P. Satzer, A. Jungbauer, A. Dürauer: Characterization of hydrodynamics and volumetric power input in microtiter plates for the scale-up of downstream operations, Biotechnology And Bioengineering, 2021, https://doi.org/10.1002/bit.27983

V. Braunschmid, K. Binder, S. Fuerst, R. Subagia, C. Danner, H. Weber, N. Schwaiger, G. Nyanhongo, D. Ribitsch, G. Gübitz: Comparison of a fungal and a bacterial laccase for lignosulfonate polymerizatio, Process Biochemistry, 2021, https://doi.org/10.1016/j.procbio.2021.07.001

W. Fuchs, F. Steger, J. Reich, D. Ribitsch, S. Rittmann, G. Bochmann: A Simple and Straightforward Method for Activity Measurement of Carbonic Anhydrases, Catalysts, 2021, https://doi.org/10.3390/catal11070819

N. Lali, A. Jungbauer, P. Satzer: Traceability of products and guide for batch definition in integrated continuous biomanufacturing, Journal Of Chemical Technology And Biotechnology, 2021, https://doi.org/10.1002/jctb.6953

H. Liu, B. Nidetzky: Leloir glycosyltransferases enabled to flow synthesis: continuous production of the natural C-glycoside nothofagin, Biotechnology And Bioengineering, 2021, https://dx.doi.org/10.1002/bit.27908

P. Nikel, D. Mattanovich: Microbial cell factories: a biotechnology journey across species , Essays In Biochemistry, 2021, https://dx.doi.org/10.1042/EBC20210037

S. Kallolimath, L. Sun, R. Palt, K. Stiasny, P. Mayrhofer, C. Gruber, B. Kogelmann, Q. Chen, H. Steinkellner: Highly active engineered IgG3 antibodies against SARS-CoV-2, Proceedings Of The National Academy Of Sciences Of The United States Of America, 2021, https://doi.org/10.1073/pnas.2107249118

L. Rotilio, A. Swoboda, K. Ebner, C. Rinnofner, A. Glieder, W. Kroutil, A. Mattevi: Structural and Biochemical Studies Enlighten the Unspeciﬁc Peroxygenase from Hypoxylon sp. EC38 as an Eﬃcient Oxidative Biocatalyst, Acs Catalysis, 2021, https://doi.org/10.1021/acscatal.1c03065

B. Grill, M. Horvat, H. Schwab, R. Gross, K. Donsbach, M. Winkler: Gordonia hydrophobica Nitrile Hydratase for Amide prepara-tion from nitrile, Catalysts, 2021, https://doi.org/10.3390/catal11111287

L. Rettenbacher, K. Arauzo-Aguilera, L. Buscajoni, A. Castillo-Corujo, B. Ferrero-Bordera, A. Kostopoulou, R. Moran-Torres, D. Núñez-Nepomuceno, . Öktem, A. Palma, B. Pisent, M. Puricelli, T. Schilling, A. Tungekar, J. Walgraeve, D. Humphreys, T. von den Haar, B. Gasser, D. Mattanovich, L. Ruddock, J. van Dijl: Microbial Protein Cell Factories Fight Back?, Trends In Biotechnology, 2021, https://doi.org/10.1016/j.tibtech.2021.10.003

T. Gassler, M. Baumschabl, J. Sallaberger, M. Egermeier, D. Mattanovich: Adaptive laboratory evolution and reverse engineering enhances autotrophic growth in Pichia pastori, Metabolic Engineering, 2021, https://doi.org/10.1016/j.ymben.2021.11.007

C. Zhong, B. Nidetzky: Precision synthesis of reducing-end thiol-modified cellulose enabled by enzyme selection, Polymer, 2021, https://doi.org/10.1038/s41428-021-00599-4

Ö. Ata-Akyol, B. Ergün, P. Fickers, L. Heistinger, D. Mattanovich, C. Rebnegger, B. Gasser: What makes Komagataella phaffii non-conventional?, Fems Yeast Research, 2021, https://doi.org/10.1093/femsyr/foab059

B. Buchner, J. Zanghellini: EFMlrs: a Python package for elementary flux mode enumeration via lexicographic reverse search, Bmc Bioinformatics, 2021, https://doi.org/10.1186/s12859-021-04417-9

M. Horvat, V. Weilch, R. Rädisch, S. Hecko, A. Schiefer, F. Rudroff, B. Wilding, N. Klempier, M. Pátek, L. Martinkova, M. Winkler: Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxim, Catalysis Science & Technology, 2021, https://doi.org/10.1039/D1CY01694F

J. Jung, D. Schachtschabel, M. Speitling, B. Nidetzky: Controllable Iterative β-Glucosylation from UDP-Glucose by Bacillus cereus Glycosyltransferase GT1: Application for the Synthesis of Disaccharide-Modified Xenobiotics, Journal Of Agricultural And Food Chemistry, 2021, https://doi.org/10.1021/acs.jafc.1c05788

S. Simić, E. Zukic, L. Schmermund, K. Faber, C. Winkler, W. Kroutil: Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods, Chemical Reviews, 2021, https://doi.org/10.1021/acs.chemrev.1c00574

I. Oroz-Guinea, C. Winkler, S. Glueck, K. Ditrich, M. Weingarten, M. Breuer, D. Schachtschabel, W. Kroutil: Ene-reductase Catalyzed Regio- and Steroselective 1,4‑Mono-Reduction of Pseudoionone to Geranylacetone, Chemcatchem, 2021, https://doi.org/10.1002/cctc.202101557

C. Rapp, S. Pival-Marko, E. Tassano, B. Nidetzky, R. Kratzer: Reductive enzymatic dynamic kinetic resolution affording 115 g/L (S)-2-phenylpropanolBMC, Bmc Biotechnology, 2021, https://doi.org/10.1186/s12896-021-00715-5

A. Christler, T. Scharl, D. Sauer, J. Köppl, A. Tscheließnig, C. Toy, M. Melcher, A. Jungbauer, A. Dürauer: Technology transfer of a monitoring system to predict product concentration and purity of biopharmaceuticals in real-time during chromatographic separatio, Biotechnology And Bioengineering, 2021, https://doi.org/10.1002/bit.27870

R. Weiß, S. Gritsch, G. Brader, B. Nikolic, M. Spiller, J. Santolin, H. Weber, N. Schwaiger, S. Pluchon, K. Dietel, G. Gübitz, G. Nyanhongo: A biobased, bioactive, low CO2 impact coating for soil improvers, Green Chemistry, 2021, https://doi.org/10.1039/D1GC02221K

G. Berg, P. Kusstatscher, F. Stocker, A. Abdelfattah, T. Cernava: Advances in understanding modes of action of microbial bioprotectants, In: Microbial Bioprotectants For Plant Disease Management, Burgleigh Dodds Science Publishing Ltd, Jürgen Kohl, Willem J. Ravensberg, Eds., 2021, https://shop.bdspublishing.com/store/bds/detail/product/3-190-9781801463270

R. Grünbichler, B. Petschacher, R. Kollmann, A. Passer, S. Grbenic: INTERNAL REPORTING ON PROCESS OPTIMIZATION MEASURES: COMBINATION OF ECONOMIC AND ENVIRONMENTAL ASPECT, Facta Universitas, Series Economics And Organization, 2021, https://doi.org/10.22190/FUEO210622030G

V. Schmieder, N. Novak, H. Dhiman, L. Nguyen Ngoc, E. Serafimova, G. Klanert, M. Baumann, H. Kildegaard, N. Borth: A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells , Biotechnology Reports, 2021, https://doi.org/10.1016/j.btre.2021.e00649

D. Széliová, J. Stor, I. Thiel, M. Weinguny, M. Hanscho, G. Lhota, N. Borth, J. Zanghellini, D. Ruckerbauer, I. Rocha: Inclusion of maintenance energy improves the intracellular flux predictions of CHO, Plos Computational Biology, 2021, https://dx.doi.org/10.1371/journal.pcbi.1009022

B. Nidetzky, C. Zhong: Phosphorylase-catalyzed bottom-up synthesis of short-chain cello-oligosaccharides and property-tunable cellulosic materials, Biotechnology Advances, 2021, https://doi.org/10.1016/j.biotechadv.2020.107633

A. Borg, K. Beerens, M. Pfeiffer, T. Desmet, B. Nidetzky: Stereo-electronic control of reaction selectivity in short-chain dehydrogenases: decarboxylation, epimerization, and dehydration, Current Opinion In Chemical Biology, 2021, https://doi.org/10.1016/j.cbpa.2020.09.010

B. Nidetzky, T. Desmet: Biocatalytic opportunities to harness the structural diversity of carbohydrates, Current Opinion In Chemical Biology, 2021, https://doi.org/10.1016/j.cbpa.2021.02.011

C. Rapp, B. Nidetzky, R. Kratzer: Pushing the limits: cyclodextrin-based intensification of bioreductions, Journal Of Biotechnology, 2021, https://doi.org/10.1016/j.jbiotec.2020.11.017

B. Nidetzky: Glycosyltransferase cascades made fit for the biocatalytic production of natural product glycosides, In: Biocatalysis For Practitioners (C. Gonzalo De Gonzalo, I. Lavandera, Editors), Wiley-Vch, Weinheim, Pp. 225 – 244., 2021, https://doi.org/10.1002/9783527824465.ch8

W. Liang, P. Wied, F. Carraro, C. Sumby, B. Nidetzky, C. Tsung, P. Falcaro: Metal-organic framework-based enzyme biocomposites, Chemical Reviews, 2021, https://doi.org/10.1021/acs.chemrev.0c01029

H. Liu, G. Tegl, B. Nidetzky: Glycosyltransferase co-immobilization for natural product glycosylation: cascade biosynthesis of the C-glucoside nothofagin with efficient reuse of enzymes, Advanced Synthesis & Catalysis, 2021, https://doi.org/10.1002/adsc.202001549

K. Zajki-Zechmeister, G. Kaira, M. Eibinger, K. Seelich, B. Nidetzky: Processive enzymes kept on a leash: how cellulase activity in multienzyme complexes directs nanoscale degradation of cellulose, Acs Catalysis, 2021, https://doi.org/10.1021/acscatal.1c03465

J. Jung, K. Schmölzer, D. Schachtschabel, M. Speitling, B. Nidetzky: Selective β-mono-glycosylation of C15 hydroxylated metabolite of the agricultural herbicide cinmethylin using Leloir glycosyltransferases, Journal Of Agricultural And Food Chemistry, 2021, https://doi.org/10.1021/acs.jafc.1c01321

A. Sigg, M. Klimacek, B. Nidetzky: Three-level hybrid modeling for systematic optimization of biocatalytic synthesis: glucosylglycerol production by enzymatic transglycosylation from sucrose, Biotechnology And Bioengineering, 2021, https://doi.org/10.1002/bit.27878

S. Schelch, M. Eibinger, S. Gross-Belduma, B. Petschacher, J. Kuballa, B. Nidetzky: Engineering analysis of multienzyme cascade reactions for 2’-sialyllactose synthesis., Biotechnology And Bioengineering, 2021, https://doi.org/10.1002/bit.27898

O. Cornelius, S. Gierlinger, R. Vielnascher, W. Gabauer, K. Prall, A. Pellis, G. Gübitz: Cultivation of heterotrophic algae on paper waste material and digestate, Algal Research, 2021, https://doi.org/10.1016/j.algal.2021.102193

K. Kremser, S. Thallner, D. Clay, S. Spiess, J. Kucera, T. Vaculovic, D. Všianský, M. Haberbauer, M. Mandl, G. Gübitz: Leachability of metals from waste incineration residues by iron- and sulfur-oxidizing bacteria, Journal Of Environmental Management, 2021, https://doi.org/10.1016/j.jenvman.2020.111734

L. Lalanne, G. Nyanhongo, G. Gübitz, A. Pellis: Biotechnological production and high potential of furan-based renewable monomers and polymers, Biotechnology Advances, 2021, https://doi.org/10.1016/j.biotechadv.2021.107707

S. Mayr, R. Subagia, R. Weiss, N. Schwaiger, H. Weber, D. Ribitsch, G. Nyanhongo, G. Gübitz: Oxidation of Various Kraft Lignins with a Bacterial Laccase Enzyme, International Journal Of Molecular Sciences, 2021, https://doi.org/10.3390/ijms222313161

S. Mayr, N. Schwaiger, H. Weber, J. Kovac, G. Gübitz, G. Nyanhongo: Enzyme Catalyzed Copolymerization of Lignosulfonates for Hydrophobic Coatings, Frontiers In Bioengineering And Biotechnology, 2021, https://doi.org/10.3389/fbioe.2021.697310

M. Nagl, O. Cornelius, L. Skopek, A. Pellis, W. Bauer, G. Nyanhongo, G. Gübitz: Biorefining: the role of endoglucanases in refining of cellulose fibers, Cellulose, 2021, https://doi.org/10.1007/s10570-021-04022-2

D. Ribitsch, G. Gübitz: Tuning of adsorption of enzymes to polymer, Methods In Enzymology, 2021, https://doi.org/10.1016/bs.mie.2020.12.010

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