The biopharmaceutical industry has witnessed remarkable growth, with biologics claiming a significant market share. CHO cells have been the backbone for producing therapeutic agents, but challenges persist, especially in the face of rising costs and the emergence of complex protein formats. Addressing these challenges requires a comprehensive understanding of CHO cell genetics and behavior, which acib has diligently pursued.
acib’s CHO-cell technology spans diverse aspects, from generating a high-quality reference genome to characterizing genetic diversity within cell lineages. Innovative tools for cell engineering and optimization of cell behavior have been established by the accessibility to genomic and epigenetic data. Moreover, acib has delved into epigenetic modulation, using non-coding RNAs and CRISPR engineering, paving the way for precise control over cellular behavior. This detailed understanding allows for improved bioprocessing, cell line optimization, and the creation of a minimal designer
acib’s CHO-cell technology has already influenced the biopharmaceutical industry by advancing media formulation, enhancing protein purification, and enabling multiplexed cell engineering. The innovative approaches developed by acib offer tangible benefits, from improved process titers to higher yields, enhanced product quality and higher stability of production cell lines. Join us in shaping the future of biopharmaceutical manufacturing.
Experts:Prof. Dr. Nicole Borth
Development status:TRL4: technology validated in lab
Keywords:Chinese Hamster Ovary (CHO) cells, Biopharmaceuticals, Epigenetics, CRISPR engineering, Metabolic modeling Industrial collaboration
Picture by DALL-E