Ginsenosides (also called panaxosides) are the well-known natural products from Ginseng (Panax) plants, which have longstanding use in traditional medicine exhibiting a variety of pharmacological effects. The content and yield of ginsenosides vary drastically not only between different species such as the Asian ginseng (Panax ginseng), the Japanese ginseng (Panax japonicus) and the American ginseng (Panax quinquefolius), but also between individual plants. This, in combination with the dependence on suitable growth conditions and land consumption, creates the need for an alternative, reliable, easy-to-access, environmentally-friendly and economic source of ginsenosides.
acib has initiated metabolic engineering of the industrial yeast Komagataella phaffii (aka Pichia pastoris) for the production of highly-valued ginsenosides, providing an inexpensive and environmentally benign way superior to extraction from ginseng roots. Yeast strains with modifications in precursor supply and integrated pathways for ginsenoside-aglycon synthesis are available. Suitable analytical methods for detection of ginsenoside aglycons have been established. acib has all the expertise in glycosylation technology required and applicable for the production of natural and new-to-nature ginsenosides. We are ready to partner with companies to develop this technology further for them.