Yeast surface display represents a powerful protein engineering technology, enabling a wide range of applications including the generation of novel antigen binding sites (also in non-antibody proteins), affinity maturation, construction of pH-dependent binding sites and protein stabilization, among many others.
Background
Engineered proteins are key components of a wide range of therapeutics and diagnostics. In vitro directed evolution of proteins by using yeast surface display comes with several critical advantages such as the eukaryotic expression machinery, quantitative sorting, precise control over selection conditions, etc. These sophisticated yeast surface display selection campaigns enable high-end protein engineering tasks, which would not be possible with standard techniques such as the hybridoma technology.
Technology
- Generation of novel antigen binding sites (in antibody- or non-antibody-based proteins)
- Affinity maturation of existing protein-protein interactions
- Engineering pH-dependent binding sites
- Protein stabilization (i.e. “repairing” unstable, poorly expressed proteins)
- Epitope mapping
- Specific recognition of certain antigen conformations/states
Offer
Under protection of a CDA/NDA we engineer proteins with ideal properties specifically tailored to your needs. These engineering campaigns can be used for (i) a multitude of different proteins to be engineered and (ii) for a wide range of desired biochemical features (see above). IP developed in such a project will fully belong to our industrial partner. Don't miss out on the opportunity to harness the capabilities of our yeast surface display technology to streamline your development. Reach out to acib to explore new partnership opportunities!
