Discovery of novel enzymes is still challenging. Functional screening is an important approach to identify new biocatalysts from living cells. Additionally, different methods of functional proteomics are available. However, it is well known that only a very small percentage of the total bacterial diversity can be cultured in the laboratory. Hence, in-silico approaches are applied to elucidate promising candidates also from non-culturable sources. In the development of biodegradable materials knowledge about the influence of the chemical structure / composition on biodegradability is essential. Again, in-silico strategies towards enzymes for environment of interest, as provided by acib, are useful to predict biodegradation.
In our labs, functional screening and in-silico methods are used to identify novel enzymes in especially underexplored environments. In addition, different methods of rational design are applied to tailor the biocatalysts for specific industrial applications. These activities involve the latest tools of biotechnology and sophisticated analytical equipment as well as facilities for scale-up.
Experts:Dr. Doris Ribitsch, Prof. Georg Gübitz, Dr. Sara Vecchiato
Development status:TRL 3-5
Novel biocatalysts, In-silico screening, Enzyme engineering, Biopolymers, Enzymatic degradation