At acib, we aim at developing an advanced monitoring system for installation directly at the wastewater treatment plants, which uses real time PCR to detect nucleic acids from pathogens in wastewater. An automated and closed system enables hands-off sample preparation followed by detection and identification of pathogen nucleic acids of various viruses e.g. SARS-CoV-2, Monkeypox, Influenza, Hanta-, Polio-, Rota-, Norovirus, etc. In a further development step an online controllable oligo nucleotide synthesis unit, as well as a sequencing unit will be integrated to detect single virus variants. The detected real-time amplification signals are automatically analyzed, evaluated, and interpreted to provide health officials with real-time data. Such devices can also be used for analysis of all kind of natural water bodies including drinking water reservoirs.