Carboligases catalyze the decarboxylation e.g. of an alpha-keto acid and simultaneous ligation to an acceptor e.g. an aldehyde, thus forming a novel C-C bond. This makes carboligases a very interesting enzyme class e.g. for the production of chiral acyloins. Incorporated into reaction cascades, carboligase chemistry is valuable for the synthesis of complex molecules.
acib has expertise in thiamine diphosphate (thDP)-dependent carboligases to fuse two aldehydes or an aldehyde with an α-hydroxyacid to give hydroxy-ketones. We showcased this for short, aliphatic acyloins for flavor and fragrance applications already, and now we are looking forward to extend the concept for other applications with you!