The critical and cost driving step in the development of viral and virus-like particles, is the production process which requires not only a deep understanding of the process mechanisms, but also high-throughput analytical tools, and state-of-the-art up- and downstream processing equipment. acib has everything you need and in addition to expertise in viral vectors and particle expression in cell culture, also extensive know-how in purification processes for virus-like particles (VLPs) and other bionanoparticles such as extracellular vesicles (e.g. exosomes).-
acib’s upstream processing infrastructure consists of bioreactor systems configured for cell culture (mammalian or insect cells) and virus applications up to 10 L and a parallel multibioreactor system. Both can be combined with an alternating tangential flow system to deliver high cell concentrations and process intensification. For downstream processing we provide a pilot-scale continuous ultracentrifuge with a fluid handling system and a preparative chromatography with MALS detector. This equipment is complemented by advanced analytical tools like nanoparticle tracking analysis, microflow cytometer, asymmetric flow field-flow fractionation and analytic HPLC with UV-MALS-DLS-RI detector. All equipment is in a dedicated BSL2 facility and can be made available for joint projects or to external users!
Experts:Dr. Patricia Pereira Aguilar, Prof. Dr. Alois Jungbauer, Prof. Dr. Reingard Grabherr, Prof. Dr. Gerald Striedner, Dr. Peter Satzer, Dr. Verena Beck
Investments, Joint Research Projects, Contract Research